Ethyl fluoroacetate supplier: Ethyl fluoroacetate preparation processes and methods

Suppliers of Ethyl Fluoroacetate_ethyl fluoroacetateUsed as an intermediate in organic synthesis. Used in the pharmaceutical industry5-Fluorouracil,5-Synthesis of fluopyrimidol, with dangerous flammability characteristics, open flame flammable; high heat release toxic fluoride gas;In case of water, moisture decomposes to form corrosive gas. Foam, dry powder and carbon dioxide extinguishing agent can be used to extinguish the fire.

Suppliers of Ethyl Fluoroacetate_ethyl fluoroacetateThe preparation process needs to use the refining unit with decompression distillation, distillation, cooling crystallization, sublimation crystallization and other distillation operation units;ethyl fluoroacetateThe detection methods include gas chromatography, liquid chromatography, infrared spectrometer, ultraviolet spectrometer, atomic absorption spectrometry, etc.ethyl fluoroacetateEnvironmental protection in the preparation process is divided into physical, chemical and biochemical methods, to achieve wastewater treatment,CODAutomatic tracking detection. Below for everyone to briefly introduceethyl fluoroacetateThe preparation process and method.

Suppliers of Ethyl Fluoroacetate_ethyl fluoroacetateThe preparation process and method:

ethyl fluoroacetateIt is obtained by the action of ethyl chloroacetate and potassium fluoride. The reactor is first added to the acetamide, in the oil bath.130-250℃ heating stirring30Minutes, remove water, then add raw materials ethyl chloroacetate and potassium fluoride, slowly heat up, under stirring, through the fractionation column.(The temperature of the fractionating column is maintained115-120℃)Distillation of the reaction product, and then through the fractionation column distillation, collection.115-120The fraction of the temperature is obtained. The specific preparation method is to add acetamide to a reaction bottle equipped with a stirrer, thermometer, and fractionation column, and heat140~160℃(bath temperature)Dehydration1h, cold120C, add ethyl chloroacetate and dry, crushed potassium fluoride. In110℃ reaction2h, slowly rise to internal temperature130C, collect the distillate, and then the internal temperature rises190C, until there is no distillate, and then reduced pressure to no distillate so far. Distillate distillate, collect114~118C fraction, getethyl fluoroacetate.