Use of ethyl difluorobromoacetate

　　ethyl difluorobromoacetateIt is a colorless and transparent liquid. In ethyl difluorobromoacetate, CF2 with strong biological activity is introduced into the compound by replacing bromine atoms. It is an important intermediate in organic synthesis and is commonly used in the synthesis of drugs with biological enzyme function and the synthesis of pesticides. The fluorine-containing position of this compound will increase the electrophilicity of the carbonyl group, that is to say, it will increase the active site of the biological enzyme. Then, let's learn about the use of ethyl difluorobromoacetate!

Fluorine atoms are the emitters of hydroxyl bioelectrons and the like, and difluoromethylene-containing compounds are effective bioactive agents. For example, the replacement of ethoxy with methylene chloride CF2, difluoromethylene is also considered to be the discharge body of ethoxy bioelectron, etc., and the reagent against HTV can be obtained. In addition, the synthesized compounds can also be reactive through the ester bond functional groups, difluoroacetate containing difluoromethylene synthetic block, derived from more related compounds. In recent years, the synthesis of fluorine-containing compounds by fluorine-containing block method has been greatly developed, so it is mostly used to synthesize fluorine-containing compounds such as medicine, pesticide intermediates, dyes and so on, which has become a research hotspot at home and abroad. For example, in addition to widely used in medicine, materials science, catalytic reaction, synthesis of 1-difluoromethyl imidazole and its derivatives, imidazole and its derivatives is an important structural unit with bioactive compounds, can also be used in the preparation of N-heterocyclic carbene precursor.

As a common metal ligand and organic small molecule catalyst, n-heterocyclic carbene is used to initiate difluoromethyl etherification reaction by heating and stirring the mixed solution, in which the matrix is benzimidazole, 2-benzenimidazole, 5-nitrobenzimidazole, 5,6-dimethylbenzimidazole, imidazole or ethyl difluoroacetate as difluoromethylation reagent, which has attracted the attention of researchers, its preparation method is the difluoroethyl acetate, substrate imidazole and its derivatives, alkali dissolved in the reaction solvent.

In addition, it can also be used in solvents.ethyl difluorobromoacetateReact with active zinc powder to obtain an organic zinc intermediate state reaction solution, thereby manufacturing a gemitabin intermediate containing iodine powder; add glycidol into solvent 2 to obtain a solution corresponding to glycidol; simultaneously pump the organic zinc intermediate state reaction solution and the acetoxypropyl formaldehyde solution into a microchannel reactor for condensation reaction to obtain an effluent, which is further oxidized to obtain the corresponding product gypsy intermediate.

In recent years, the synthesis of fluorine-containing compounds by fluorine-containing block method has been greatly developed and has become a research hotspot at home and abroad. For example, in the synthesis of 1-difluoromethylimidazole and its derivatives, imidazole and its derivatives are important structural units with bioactive compounds, and difluoroacetate contains difluoromethylene synthetic blocks, so it is mostly used in the synthesis of pharmaceuticals, pesticide intermediates, dyes and other fluorine-containing compounds. In addition to being widely used in medicine, materials, catalytic reactions, it has attracted the attention of scientific researchers, the preparation method is to dissolve ethyl difluorobromoacetate, the substrate imidazole and its derivatives, and the base in the reaction solvent, and can also be used for the preparation of N-heterocyclic carbene precursors. N-heterocyclic carbene is used as a common metal ligand and organic small molecule catalyst, and the difluoromethyl etherification reaction is initiated by heating and stirring the mixed solution, in which the substrate is benzimidazole, 2-benzimidazole, 5-nitrobenzimidazole, 5,6-dimethylbenzimidazole, imidazole or ethyl difluorobromoacetate as difluoromethylation reagent.

In addition, it can also be used to react ethyl difluorobromoacetate with active zinc powder in a solvent to obtain an organic zinc intermediate reaction solution, thereby manufacturing a gemitabin intermediate containing iodine powder; Glycidol is added to solvent 2 to obtain a solution corresponding to glycidol; The reaction solution in the organic zinc intermediate state and the solution of acetoxypropyl formaldehyde are respectively pumped into a micro-channel reactor for condensation reaction at the same time to obtain an effluent and further oxidation, the corresponding product gypsy intermediate was obtained.

The above is the use of ethyl difluorobromoacetate, if you need to know more, you can contact us at any time!