Ethyl fluoroacetate manufacturer_classification of synthesis process of ethyl difluorobromoacetate

Ethyl fluoroacetate manufacturers_ethyl difluorobromoacetateIt is an ester derivative and can be used as a pharmaceutical intermediate.ethyl difluorobromoacetateThe compound is an intermediate of synthetic drugs and high-energy materials, such as ethyl difluorobromoacetate is an intermediate of the drug gemcitabine, and its chemical properties are boiling points.112℃, density1.583.ethyl difluorobromoacetateIt is a colorless and transparent liquid, which is an important synthetic intermediate, commonly used in the synthesis of drugs and pesticides with biological enzyme function. Inethyl difluorobromoacetateIn, by replacing the bromine atom, the biologically activeCF2Introduced into the compound, this kind of compound alpha fluorine-containing carbonyl electrophilicity increased, that is, increased the active site of the enzyme. Fluorine atoms are the bioisobodies of hydroxyl groups, difluoromethylene groups are also considered to be the bioisobodies of ethoxy groups, and compounds containing difluoromethylene groups are useful bioactive agents.

Ethyl fluoroacetate manufacturers_ethyl difluorobromoacetateClassification of synthetic process:

1.Tetrafluoroethylene as raw material

Synthesis of bromodifluoroacetyl chloride using tetrafluoroethylene as raw material, tetrafluoroethylene and sodium methoxide in 60C under the condition of Mr. into three fluorine vinyl methyl ether. It is then added with bromine and then oxidized to remove the ether to give bromodifluoroacetyl chloride. But the reaction yield is relatively low, according to the calculation of tetrafluoroethylene,ethyl difluorobromoacetateThe yield is in percent30Left and right.

2.using chlorotrifluoroethylene as raw material

Synthesis of chlorotrifluoroethylene as raw material CF2Br CFCl Brand then oxidized with sulfuric acid and sulfur trioxide.SO3/CF2Br CFCl Brmolar ratio equal1.5percent of the number40of oleum, reaction20hObtain a yield of percent85Brominated difluoroacetyl chloride, separated from the resulting brominated difluoroacetyl chloride trapped in anhydrous ethanolethyl difluorobromoacetate.