The direct sales department of ethyl difluorobromoacetate manufacturer talks about the application of ethyl difluorobromoacetate

Ethyl difluorobromoacetate is a colorless and transparent liquid. The direct sales department of ethyl difluorobromoacetate manufacturer believes that it is an important organic synthesis intermediate for the synthesis of drugs and pesticides with biological enzyme functions. In ethyl difluorobromoacetate, instead of bromine atoms, the biologically active CF2 is introduced into the compound. The position fluorine in these compounds increases the electrophilicity of the carbonyl group. That is, increase the active site of the biological enzyme. Plutonium atoms are ligands such as bioelectrons for hydroxyl groups, dimethyl is also considered to be ligands such as bioelectrons for epoxy groups, and compounds containing dimethyl are effective biologically active reagents. For example, the effect of an anti-HTV agent can be achieved by replacing ethoxy with dimethyl CF2. The synthesized compound can induce more related compounds through the reactivity of the ester bond functional group.

Ethyl difluorobromoacetate factory direct sales department talk about application

In recent years, great progress has been made in the synthesis of fluorine-containing compounds by fluorine-containing block method. Because of the synthetic block containing difluoromethyl, difluorobromoacetate has been widely used in the synthesis of fluorine-containing compounds such as drugs, pesticide intermediates and dyes, which has become a hot research topic at home and abroad. For example, in the case of synthesizing 1-DIPLUM Midazol and derivatives thereof, imidazole and derivatives thereof have been widely used in medicine, materials science, catalytic reactions, and also in the preparation of N-heterocyclic KABIN precursors.

N-heterocyclic carbene, as a common metal ligand and organic small molecule catalyst, has been widely concerned by researchers. It is produced by dissolving dibromoethyl ester, a substrate, a derivative thereof and a base in a reaction solvent. The mixture is heated to produce a dibromination reaction where the substrate is benzo, 2-phenylbenzo, 5. Ethyl difluorobromoacetate is used as difluoromethylation reagent, which consumes ozone and protects the green environment. The overall reaction conditions are mild and the post-treatment is simple.

In addition, it can also be used for the preparation of gemcitabine intermediates, which includes reacting ethyl ester and active zinc powder in solvent 1, containing a reaction solution in the intermediate state of organic zinc, and adding iodine powder. Acetylidene glycerol was added to solvent 2 to give a solution of the corresponding acetylidene glyceraldehyde. The direct marketing department of the manufacturer of ethyl difluorobromoacetate suggests that the reaction solution in the intermediate state of organic zinc and the solution of acetylidene glyceraldehyde are respectively pumped into the microchannel reactor for contraction reaction at the same time to obtain the effluent, which is acidified to obtain the corresponding product gemcitabine intermediate.

Ethyl difluorobromoacetate manufacturers direct sales department share preparation

1. Using tetrafluoroethylene as raw material

Bromodifluoroacetyl chloride was synthesized from tetrafluoroethylene, trifluoroethylene methyl ether was prepared from tetrafluoroethylene and sodium methyl alcohol under the condition of 60, bromine was added, and then bromodifluoroacetyl chloride was obtained by oxidation with chlorosulfonic acid. But the reaction rate is relatively low. Calculated by Teflon, the yield of bromine and diacetyl chloride is about 30%.

2. Using chlorotrifluoroethylene as raw material

CF2Br CFCl Br was synthesized from chlorotrifluoroethylene as raw material, and then acidified with sulfuric acid and trioxide in the presence of mercury oxide. The molar ratio of SO3/CF2Br CFCl Br was equivalent to 40% of the 1.5 amount of nicotinic acid. 85% bromodifluoroacetyl chloride was obtained when the reaction was carried out for 20h, and the precipitated bromodifluoroacetyl chloride was obtained.

using vinylidene fluoride as raw material

Through the continuous bromination of 1,1-difluoroethylene under solvent-free and UV irradiation, 1,1-dibromo -2,2-difluoroethylene is first prepared by debromination hydrogen reaction in aqueous alkaline medium, and 1,1-dibromo -2,2-difluoroethylene is self-oxidized, and dibromodifluoroethylene is separated after separation and distillation.

Using 1,2-dibromo -1,1-diroro-2, 2 dichloroethane as raw material

1,2-Dibromo-1,1-difluoro -2,2-dichloroethane is converted to bromine, difluoroacetyl halide (acid bromide or acid chloride) and reacted directly with alcohol or water. The direct sales department of ethyl difluorobromoacetate manufacturer believes that in the dehydrochlorination reaction, the phase change is the presence of a catalyst. The molar ratio of sodium hydroxide to 1,2-dibromo -1,1-difluoro -2,2-dichloroethane is 1.3 and the reaction temperature is 50. The bromination reaction is carried out only under bubbles in bromine. The temperature when bromine is added can reach 55 and the yield can reach 84%. In the oxidation and esterification reaction, the molar ratio of 1,2-dibromo -1,1-difluoro -2,2-dichloroethane to oleum is 0.56, the reaction temperature is 70, the yield is 80%, and the total yield of the process is 67%. The method can obtain a large amount of HF or inorganic fluoride waste liquid, mercury salt catalyst and industrial raw materials in the preparation process, and has industrial feasibility.